Thermoresponsive nanogels for prolonged duration local anesthesia.

Nanogel scavengers for drugs: local anesthetic uptake by thermoresponsive nanogels.

The use of functional nanogels based on poly(N-isopropylacrylamide) for effectively scavenging compounds (here, the model drug bupivacaine) is demonstrated using an in vitro cell-based assay. Nanogels containing higher loadings of acidic functional groups or more core-localized functional group distributions bound more bupivacaine, while nanogel size had no significant effect on drug binding. I...

Fabrication of thermoresponsive nanogels by thermo-nanoprecipitation and in situ encapsulation of bioactives

Biocompatibility and characterization of polyglycerol-based thermoresponsive nanogels designed as novel drug-delivery systems and their intracellular localization in keratinocytes.

Novel nanogels that possess the capacity to change their physico-chemical properties in response to external stimuli are promising drug-delivery candidates for the treatment of severe skin diseases. As thermoresponsive nanogels (tNGs) are capable of enhancing penetration through biological barriers such as the stratum corneum and are taken up by keratinocytes of human skin, potential adverse co...

Comparison of the application of lidocaine, lidocaine-dexamethasone and lidocaine-epinephrine for caudal epidural anesthesia in cows

The aim of the present study was to determine whether the addition of dexamethasone (DEX) or epinephrine to lidocaine (LID) altered the characteristics of anesthesia and cardiorespiratory variables following caudal epidural application in cows. Twenty adult dairy cows were randomly assigned to receive one of the treatments of LID (0.2 mg/kg), DEX (8 mg), lidocaine-dexamethasone (LIDEX; 0.2 mg/k...

What Is the Main Reason of Shortening Duration of Action of Local ‎Anesthetics Used for Spinal Anesthesia in Opium Addicted Patients?‎

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